Synthesis of Methylisobutylcarbinylsarin (GH) by APC process

[Basquyatti]

GH is obtained similarly to Sarin using 3 steps, the first step is used for the manufacture of methylphosphonyl dichloride against Kinnear perren, an equimolar mixture between phosphorus trichloride, aluminum trichloride and chloromethane react to form a complex called APC, this is extracted and purified by conventional means, the second step consists of dissolving the APC in Dichloromethane and hydrolyzing it in hydrochloric acid in a molar ratio of 1 to 7, at the end of the reaction the lower phase is extracted and the DC separated from that solution, the DC is purified by common means, the third step is to react DC with sodium fluoride and 4-methylpentanol in molar ratio of 1: 1: 1, common means are used to dissolve the mixture and to promote At the end of the reaction the GH is extracted by common means.

https://fas.org/irp/threat/cbw/1951_CancellationofGHasadevelopmentprocurementtypeandrelatedaction.pdf

https://fas.org/irp/threat/cbw/1949_agentsoftheg-series.pdf

https://fas.org/irp/threat/cbw/1953_Significantaccomplishments_chemical%20corps.pdf